MFS Quick Fly Fishing Tip: Tying the Blood Knot – Learning to tie the Blood Knot takes practice. However, the Blood Knot provides one of the smoothest transitions between sections of leader material of any of the knot available. The Murray’s Fly Shop Hand Tied Leaders, including the Bright Butt Leaders, Classic Leaders, Nymphing Leaders, Spey Leaders, Fluorocarbon Leaders, Big Game Leaders and Bass Bug Leaders are all tied with Blood Knots. Are you still having trouble tying this knot after watching all the videos you can find? Stop by the Fly Shop in downtown Edinburg, Virginia for free one on one instruction about how to tie the Blood Knot.